CRABP12

CRABP12, also known as Cellular Retinoic Acid Binding Protein 12, is a protein encoded by the CRABP12 gene. This gene is found in various organisms, including humans. CRABP12 belongs to a family of proteins that are involved in the intracellular transport and metabolism of retinoids, particularly retinoic acid. Retinoic acid is a crucial signaling molecule derived from vitamin A that plays a vital role in a wide range of biological processes, including embryonic development, cell differentiation, and homeostasis.

The specific function of CRABP12 within the retinoid signaling pathway is still an area of active research. However, it is generally understood that CRABP proteins act as chaperones, binding to retinoic acid and modulating its availability to nuclear receptors that regulate gene expression. This binding can either facilitate the delivery of retinoic acid to its targets or sequester it, thereby influencing the strength and duration of the signaling response. Studies have suggested that CRABP12 may play a role in specific tissues or under particular physiological conditions. Understanding CRABP12's precise interactions and regulatory mechanisms could provide insights into developmental abnormalities and diseases associated with retinoid signaling dysregulation.