CHD34

CHD34, or chromodomain helicase DNA-binding protein 34, is a protein encoded by the CHD34 gene and belonging to the chromodomain helicase DNA-binding (CHD) family of ATP-dependent chromatin remodeling enzymes. The CHD family regulates access to genomic DNA by altering nucleosome structure and positioning, thereby influencing transcription and other DNA-templated processes. Members of this family typically feature an ATPase motor related to the SNF2 family and chromodomains that can recognize histone modifications, with additional regulatory domains across different CHD proteins. The specific domain organization of CHD34 is not as fully characterized as some other CHD members, but it is expected to share the core features of CHD remodelers.

Functional information on CHD34 remains limited. Based on family membership, CHD34 is presumed to participate in chromatin remodeling to modulate gene expression and to influence developmental programs and cellular differentiation. It may form or be part of larger chromatin remodeling complexes, but the exact interacting partners and complex composition for CHD34 have not been decisively defined in the literature to date.

Expression data indicate that CHD34 is transcribed and translated across multiple tissues, with expression levels that can vary by developmental stage and physiological context. Clinically, there are no well-established disease associations that are universally attributed to CHD34, though dysregulation of CHD family members is linked to developmental disorders and cancer in general, leaving the precise role of CHD34 in health and disease an area for further study.

Evolutionarily, CHD34 has orthologs in various vertebrates, and comparative studies in model organisms may help clarify its functions and regulatory networks.