CDPCholinPfad
CDPCholinPfad (often referred to in English as the CDP‑choline pathway or Kennedy pathway) is a conserved biochemical route for the de novo synthesis of phosphatidylcholine, a major phospholipid of eukaryotic cell membranes. The pathway converts free choline into phosphatidylcholine through three enzymatic steps: phosphorylation of choline to phosphocholine by choline kinase; activation of phosphocholine to cytidine diphosphate‑choline (CDP‑choline) by CTP:phosphocholine cytidylyltransferase (CCT); and transfer of the phosphocholine moiety to diacylglycerol by choline phosphotransferase (CPT or CEPT) to form phosphatidylcholine.
The CDPCholinPfad operates primarily at the endoplasmic reticulum and nuclear envelope and is central to membrane
Dysfunction of the CDPCholinPfad has been implicated in liver disease, neurodegeneration and altered lipid metabolism. CDP‑choline