CDK3

CDK3, also known as cyclin-dependent kinase 3, is a member of the cyclin-dependent kinase (CDK) family, which plays a crucial role in cell cycle regulation and other cellular processes. CDK3 is a serine/threonine protein kinase that forms a complex with cyclin D3, a type of cyclin protein. This complex is involved in the G1 phase of the cell cycle, where it promotes cell growth and prepares the cell for DNA synthesis.

CDK3 is expressed in various tissues and is involved in multiple biological processes beyond cell cycle regulation. It has been implicated in cell differentiation, apoptosis, and the regulation of gene expression. CDK3 also plays a role in cancer development, as its dysregulation has been observed in several types of tumors.

The CDK3 gene is located on chromosome 12q24.3 in humans. Mutations in the CDK3 gene have been associated with various genetic disorders, including familial adenomatous polyposis (FAP) and Peutz-Jeghers syndrome (PJS). These disorders are characterized by the development of multiple polyps in the gastrointestinal tract and other organs.

In summary, CDK3 is a serine/threonine protein kinase that forms a complex with cyclin D3 and is involved in cell cycle regulation, cell differentiation, apoptosis, and gene expression. Its dysregulation has been linked to cancer development and genetic disorders. Further research is needed to fully understand the roles and mechanisms of CDK3 in cellular processes and disease.