CDK13

CDK13, also known as Cyclin-dependent kinase 13, is a protein-coding gene found in humans. It is a member of the cyclin-dependent kinase (CDK) family, which are enzymes that regulate cell division and gene transcription. CDK13 plays a crucial role in various cellular processes, including DNA replication, cell cycle progression, and the regulation of gene expression.

The CDK13 protein functions by phosphorylating target proteins, thereby altering their activity and downstream signaling pathways. It is known to interact with a variety of other proteins, including cyclins and transcription factors, which are essential for proper cellular function. The precise mechanisms by which CDK13 exerts its regulatory effects are still under active investigation.

Mutations or dysregulation of CDK13 have been associated with several human diseases, including certain types of cancer and developmental disorders. For instance, aberrant CDK13 activity has been observed in some hematological malignancies and solid tumors, suggesting its potential involvement in tumorigenesis. Furthermore, genetic variations in CDK13 have been linked to intellectual disability and other congenital anomalies. Research into the specific roles of CDK13 in health and disease continues to advance our understanding of its significance.