CDHR3rhinovirus

CDHR3rhinovirus refers to the interaction between a specific human gene, CDHR3 (Cadherin Repeat Protein 3), and human rhinovirus (HRV). CDHR3 is a protein primarily expressed in the respiratory epithelium. It has been identified as a key receptor for certain species of human rhinovirus, particularly HRV-C. This interaction is crucial for the virus to enter and infect host cells.

Human rhinoviruses are a major cause of the common cold, a widespread respiratory illness. HRV-C is one of the three species of HRV and is often associated with more severe respiratory symptoms, including asthma exacerbations and pneumonia, especially in children. Studies have shown that variations or polymorphisms in the CDHR3 gene can influence an individual's susceptibility to HRV-C infection and the severity of their respiratory illness. Some genetic variants of CDHR3 may lead to increased or decreased binding affinity for HRV-C, thereby impacting the risk of infection and disease outcome. Understanding this receptor-virus interaction provides insights into the pathogenesis of rhinovirus infections and may offer targets for therapeutic interventions.