CDC1

cDC1 refers to a subset of dendritic cells known as classical dendritic cells type 1. These cells are crucial players in the adaptive immune system, primarily responsible for initiating T helper 1 (Th1) immune responses. They are characterized by their expression of specific surface markers, though these can vary depending on the species and context. cDC1s are potent antigen-presenting cells, meaning they capture, process, and present foreign antigens to T cells. Their unique ability lies in their capacity to cross-present exogenous antigens, which are antigens taken from outside the cell, onto MHC class I molecules. This process is vital for activating cytotoxic T lymphocytes (CTLs), which are essential for clearing viral infections and eliminating tumor cells. cDC1s are typically found in various tissues, including the skin, lymphoid organs, and mucosal surfaces, where they constantly survey for threats. Their development is tightly regulated by transcription factors such as BATF3, which are essential for their differentiation and function. Dysregulation of cDC1 activity has been implicated in various immune-related diseases, highlighting their importance in maintaining immune homeostasis and effective defense against pathogens.