CCKcholescintigraphy
CCK-cholescintigraphy, also known as cholecystokinin cholescintigraphy, is a nuclear medicine test that uses a radiotracer to evaluate biliary tract function, particularly gallbladder emptying. The procedure typically employs technetium-99m labeled bile analogs (such as mebrofenin or disofenin). After intravenous injection of the radiotracer, dynamic imaging is performed to visualize hepatic uptake, biliary excretion, and gallbladder filling. Cholecystokinin (or its analog sincalide) is then administered to provoke gallbladder contraction. Additional imaging measures the radiotracer ejected from the gallbladder, yielding a gallbladder ejection fraction (GBEF).
Interpretation centers on gallbladder visualization and ejection. Non-visualization of the gallbladder on baseline imaging or persistent
Indications include evaluation of suspected acute cholecystitis when ultrasound is inconclusive, assessment of biliary colic due
Limitations include dependence on fasting state, hepatocellular disease, recent meals, and medications affecting bile flow. Radiation