CAMSAP3

CAMSAP3, also known as Patronin, is a protein encoded by the CAMSAP3 gene in humans. This protein plays a crucial role in the organization and stabilization of microtubules, which are essential components of the cell's cytoskeleton. Microtubules are dynamic structures involved in various cellular processes, including cell division, intracellular transport, and maintaining cell shape.

CAMSAP3 specifically localizes to the minus ends of non-centrosomal microtubules. It acts as a microtubule-associated protein, binding to the growing ends of these filaments and preventing their depolymerization. This function is vital for the formation of stable microtubule arrays, particularly in interphase cells and during the establishment of neuronal polarity. By stabilizing microtubule minus ends, CAMSAP3 contributes to the directional growth of microtubules and their proper arrangement within the cell.

Research has indicated that CAMSAP3 is involved in critical cellular functions such as cell migration and cytokinesis, the process by which a cell divides into two daughter cells. Dysregulation or mutations in CAMSAP3 have been linked to certain developmental abnormalities, highlighting its importance in proper cellular development and function. Its role in maintaining microtubule stability makes it a key player in cellular architecture and dynamics.