CAMSAP1

CAMSAP1, also known as CALCIUM MODULATED SENSITIVE CHROMOSOMAL ATTACHMENT PROTEIN 1, is a protein encoded by the CAMSAP1 gene. This gene is located on chromosome 17 in humans. CAMSAP1 is a component of the microtubule cytoskeleton and plays a crucial role in cell division, specifically during mitosis.

The protein is a member of the CAMSAP family, which are known for their ability to bind to the plus ends of microtubules. This binding is important for regulating microtubule dynamics, including growth and stability. During mitosis, CAMSAP1 is involved in the formation and maintenance of the mitotic spindle, which is essential for the accurate segregation of chromosomes to daughter cells. It contributes to the organization of microtubules emanating from the spindle poles and their interaction with chromosomes.

Dysregulation of CAMSAP1 has been implicated in various cellular processes and may be associated with certain diseases, although further research is ongoing. Its precise mechanisms of action and interactions with other cellular proteins are areas of active investigation in cell biology and cancer research.