CALML5s

CALML5s, or calmodulin-like 5 proteins, are small calcium-binding proteins related to calmodulin and members of the calmodulin-like (CALML) family. Like other CALML proteins, CALML5s are predicted to bind calcium via EF-hand motifs and to undergo conformational changes that regulate interactions with target proteins. In humans, the CALML5 gene encodes a protein that is mainly expressed in epidermal keratinocytes, with additional expression in select neural tissues.

Functionally, CALML5s are believed to participate in intracellular calcium signaling and to influence processes such as keratinocyte differentiation, cell adhesion, or signal transduction, although precise molecular roles are not fully defined. Evolutionarily, CALML5 and related CALML family members are conserved across vertebrates, indicating an ancient role in calcium signaling. Research on CALML5 includes its potential use as a biomarker for epidermal differentiation in skin pathology, but its clinical utility remains to be established. Overall, CALML5s represent a family of calcium-binding proteins with tissue-specific expression and roles in calcium-dependent signaling, subject to ongoing investigation.