CALHM13

CALHM13 is a designation that has appeared in some discussions as a potential member of the calcium homeostasis modulator (CALHM) family of membrane channels. Unlike established CALHM family genes, there is no officially recognized gene symbol CALHM13 in major databases such as HGNC, NCBI Gene, or UniProt, and there is no widely validated experimental evidence for a CALHM13 protein. As a result, information about CALHM13—including its existence, expression, sequence, or function—remains uncertain and largely speculative.

Because there is no confirmed CALHM13 gene, there is no published, peer‑reviewed data on its topology, structural features, or tissue distribution. The CALHM family is known for four‑transmembrane domain channels that form large, oligomeric pores and can mediate ATP release in neurons and other cells. If CALHM13 were to be validated as a true family member, it would be expected to undergo the same general characterization, but such attributes are currently theoretical.

In the absence of formal validation, any references to CALHM13 should be treated with caution and cross‑checked against authoritative resources. Future genomic and proteomic studies could establish whether a CALHM13 ortholog or splice variant exists in a particular species and whether it has functional properties consistent with other CALHM family members. Until then, CALHM13 remains an unconfirmed and uncharacterized designation.

See also: CALHM1, CALHM2, CALHM3, CALHM4, CALHM5, CALHM6.