CAATbox
The CAAT box is a cis-regulatory element found in the promoter regions of many eukaryotic genes. It is a short DNA motif that serves to influence transcription initiation by helping recruit the transcriptional machinery. The core consensus sequence is typically CCAAT, with common variants such as GGCCAATCT. In many genes the CAAT box is located about 75 to 80 bases upstream of the transcription start site, though its exact position can vary among promoters.
The CAAT box functions to enhance transcription efficiency and, in some promoters, is essential for robust
The primary proteins known to bind the CAAT box are members of the NF-Y family (nuclear factor
Biological significance and evolutionarily conserved nature of the CAAT box reflect its role in modulating transcription