Butamirat

Butamirat, sometimes spelled butamirate, is a cough suppressant (antitussive) used in some countries to relieve non-productive cough caused by upper respiratory irritation or viral infections. It is commonly formulated as the citrate salt (butamirat citrate) in oral syrups and tablets and sold under various brand names.

The exact mechanism of butamirat is not fully established. It is believed to reduce cough reflex activity, potentially through central action in the brainstem and/or modulation of sensory input from the airways. It is a non-narcotic medication and does not typically cause significant respiratory depression at therapeutic doses.

Clinical use of butamirat is for temporary relief of coughing in adults and, in some markets, children, with guidance for short-term use. It is not intended for a productive cough where expectoration is needed. The recommended duration of therapy is usually brief, and patients should follow local dosing instructions.

Safety and interactions: Common adverse effects include mild drowsiness, nausea, or digestive upset. Serious adverse events are uncommon. Butamirat should be used with caution in pregnancy or breastfeeding unless advised by a clinician. It is contraindicated in individuals with hypersensitivity to the drug. Caution is advised when consuming alcohol or other central nervous system depressants, as these can enhance sedative effects.

Regulatory status varies by country; butamirat is not approved in all jurisdictions. In some regions, it is available in combination products for cold and flu symptoms. As with any medication, users should consult a healthcare professional for appropriate use and potential drug interactions.