Bloodretinal
Bloodretinal refers to the blood-retinal barrier (BRB), a selective interface that regulates exchanges between the bloodstream and retinal tissue. The BRB has two components: the inner BRB, formed by retinal microvascular endothelial cells sealed by tight junctions and supported by pericytes and glial endfeet; and the outer BRB, formed by the retinal pigment epithelium (RPE), whose tight junctions restrict passage between the choroidal circulation and the neural retina. Together, these barriers maintain retinal homeostasis and protect neural tissue from fluctuations in blood composition.
The BRB's primary function is to preserve the neural retina's specialized environment. It regulates ion and
Dysfunction of the BRB is central to many retinal diseases. Breakdown can lead to macular edema, retinal
Management focuses on reducing leakage and protecting retinal structure. Treatments include intravitreal anti-VEGF agents, corticosteroids, and