Biomarkörsletning
Biomarkörsletning is a process used in biology and clinical chemistry to remove one or more biomarkers from a sample or analytic workflow. The goal is to reduce interference from dominant components and to improve the detection and quantification of target, often low-abundance, biomarkers. By removing competing molecules, the analytical dynamic range can be expanded and downstream assays such as mass spectrometry or immunoassays can perform more reliably.
The term is commonly encountered in proteomics and plasma sample preparation. Biomarkörsletning is used to deplete
Methods used to achieve biomarkörsletning include affinity-based depletion with antibody columns, immunodepletion, dye-ligand affinity approaches, size-exclusion
Advantages of biomarkörsletning include improved sensitivity and a broader dynamic range, which can aid biomarker discovery
In Swedish scientific literature the term biomarkörsletning is used to describe these sample-cleanup or depletion steps,