BioIDAPEX

BioIDAPEX is a novel bioanalytical method that combines the principles of immobilized aqueous-phase extraction (IDAPE) with sample dispersion-enhanced liquid-phase extraction (DAPE-LPEx). This hybrid technique is designed to selectivity extract and quantify biomolecules, including proteins, peptides, and small molecules, from biological samples.

The BioIDAPEX method involves the use of a mixed-mode sorbent that selectively captures target analytes, allowing for efficient extraction and removal of non-target compounds. The DAPE-LPEx component of the method is designed to enhance sample dispersion and reduce matrix effects, resulting in improved sensitivity and accuracy.

BioIDAPEX has been demonstrated to be a versatile and efficient technique for a wide range of applications, including drug discovery, biomarker identification, and metabolomics. The method has been used to extract and analyze a variety of biomolecules, including peptides, proteins, and small molecule metabolites, from various biological matrices, including plasma, serum, and tissue samples.

Compared to traditional bioanalytical methods, BioIDAPEX offers several advantages, including reduced sample preparation time, increased selectivity, and improved sensitivity. The method is also compatible with a range of detection technologies, including mass spectrometry and liquid chromatography.

BioIDAPEX has been the subject of several studies and publications, with many demonstrating its effectiveness in a variety of analytical applications. As a result, the method has gained recognition as a valuable tool in the field of bioanalysis, offering improvements in efficiency, selectivity, and sensitivity. Continued development and refinement of the BioIDAPEX method are expected to expand its applications and further solidify its position in the field of bioanalysis.