Bh1

BH1 refers to two distinct concepts in different domains. In molecular biology, BH1 stands for Bcl-2 homology 1, a conserved protein domain found within the Bcl-2 family. The Bcl-2 family includes both anti-apoptotic and pro-apoptotic proteins that regulate apoptosis, and the BH1 domain is one of a set of four Bcl-2 homology regions (BH1–BH4) that characterize these proteins. In anti-apoptotic members such as Bcl-2, Bcl-xL, and Mcl-1, the BH1 (along with BH2) contributes to forming a hydrophobic groove that binds the BH3 domain of pro-apoptotic proteins, thereby modulating mitochondrial outer membrane permeabilization and cell fate under stress. The interplay among the BH1–BH4 domains influences whether a cell survives or undergoes apoptosis, with particular relevance to cancer biology and therapeutic targeting.

In geography, BH1 is a postcode district in the Bournemouth area of Dorset, England. It lies within the broader BH postcode area and is used for mail delivery, address identification, and navigation. The designation appears on maps, local directories, and geographic information systems to identify central parts of the town and its surrounding services.

Overall, BH1 serves as an example of how the same alphanumeric code can denote a structural motif in molecular biology and a geographic district in the United Kingdom, each with its own domain-specific significance.