BZelllinie

BZellLinie refers to a specific type of genetically engineered B-cell line used primarily in research and diagnostic applications, particularly in the field of immunology and cancer biology. These lines are derived from B lymphocytes, which are a type of white blood cell responsible for producing antibodies. The term "BZellLinie" is a German abbreviation for "B-Zell-Linie," translating to "B-cell line" in English.

BZellLinie cells are often created through techniques such as immortalization, where normal B cells are transformed to become continuously dividing cells. This can be achieved using viral vectors like Epstein-Barr virus (EBV) or through genetic modifications involving oncogenes. These lines are valuable tools for studying B-cell development, function, and disease mechanisms, such as autoimmune disorders or malignancies like lymphoma or multiple myeloma.

In research, BZellLinie can be used to model specific immune responses, produce monoclonal antibodies, or investigate signaling pathways within B cells. For diagnostic purposes, some BZellLinie are employed in assays to detect antigens or antibodies, aiding in the identification of diseases or monitoring immune status. However, their use must be carefully regulated due to potential risks, such as contamination or ethical concerns regarding the creation of cell lines from human subjects.

Standardization and quality control are essential when working with BZellLinie to ensure reproducibility and safety. These lines are often shared through repositories like the ATCC (American Type Culture Collection) or other scientific databases, facilitating global collaboration in biomedical research.