BRG1associated

BRG1associated refers to proteins or complexes that interact with BRG1. BRG1, also known as SMARCA4, is a catalytic subunit of the SWI/SNF (Switch/Sucrose Non-Fermentable) family of chromatin remodeling complexes. These complexes play crucial roles in regulating gene expression by altering the structure of chromatin, making it more or less accessible to transcription machinery. The proteins that associate with BRG1 are therefore integral components of these chromatin remodeling machines.

The specific BRG1-associated proteins can vary depending on the particular SWI/SNF complex. Different subclasses of SWI/SNF complexes exist, each with distinct subunit compositions and functional specificities. These associated proteins often contribute to the recruitment of the complex to specific genomic locations, provide additional enzymatic activities, or help to stabilize the complex. Examples of proteins that can associate with BRG1 include other subunits of the SWI/SNF complex like SMARCB1 (INI1), SMARCC1 (SNF2L), and SMARCD1, as well as various regulatory proteins.

Dysregulation or mutations in BRG1 or its associated proteins can lead to developmental disorders and various types of cancer. Understanding the repertoire of BRG1-associated proteins is essential for comprehending the intricate mechanisms of chromatin remodeling and its impact on cellular processes. Research in this area aims to identify these interacting partners to elucidate their precise roles in health and disease, potentially paving the way for targeted therapeutic interventions.