BRCA2related

BRCA2related refers to conditions or risks associated with mutations in the BRCA2 gene. BRCA2, which stands for Breast Cancer gene 2, is a tumor suppressor gene. Its primary function is to help repair damaged DNA and to maintain the stability of the cell's genetic material. When a BRCA2 gene is mutated, it can lead to an increased risk of developing certain types of cancer.

Individuals who inherit a harmful mutation in one copy of the BRCA2 gene have a significantly higher lifetime risk of developing breast cancer, ovarian cancer, prostate cancer, and pancreatic cancer. These mutations are inherited in an autosomal dominant pattern, meaning that only one copy of the mutated gene from a parent is sufficient to increase the risk.

BRCA2-related cancers can occur at younger ages compared to sporadic cancers. Genetic testing is available to identify BRCA2 mutations. For individuals with a known BRCA2 mutation, increased surveillance, risk-reducing surgeries, and targeted therapies may be recommended to manage their cancer risk. It is important for individuals with a family history of these cancers to discuss their potential risk with a healthcare provider or genetic counselor.