BPTES
BPTES is a small-molecule inhibitor of the mitochondrial enzyme glutaminase GLS1. Glutaminase converts glutamine to glutamate, feeding the production of α-ketoglutarate for the tricarboxylic acid cycle and biosynthesis. BPTES acts as an allosteric inhibitor that binds to GLS1 and reduces its catalytic activity, thereby limiting glutaminolysis in cells.
In cell and enzyme assays, BPTES demonstrates selectivity for GLS1 over GLS2 and other related enzymes, with
Usage and context: BPTES is widely used as a research tool to explore the role of glutamine
Discovery and related compounds: BPTES was described as a potent GLS1 allosteric inhibitor identified through screening