BMP10mediated

BMP10-mediated signaling refers to the cellular responses initiated by the bone morphogenetic protein 10 (BMP10), a ligand of the transforming growth factor beta (TGF-β) superfamily. In vertebrates, BMP10 is predominantly expressed in the heart and vascular endothelium, and its signaling influences cardiac development and vascular homeostasis. Many studies indicate that BMP10 acts through a receptor complex that includes the type I receptor ALK1 (ACVRL1) and a type II receptor such as BMPR2, with endoglin (ENG) serving as a co-receptor in endothelial cells. Upon ligand binding, SMAD1/5/8 are phosphorylated, form a complex with SMAD4, and translocate to the nucleus to regulate transcription of target genes.

Key target genes are involved in cell cycle control and differentiation, including members of the ID family, such as ID1 and ID3, along with other BMP-responsive genes that modulate endothelial proliferation and cardiomyocyte maturation. BMP10 signaling often interacts with BMP9 signaling, and together they help coordinate vascular remodeling and heart morphogenesis.

Physiologically, BMP10-mediated signaling is essential for proper heart development, including trabeculation and chamber maturation, and it contributes to the maintenance of vascular integrity in adulthood. The pathway is modulated by extracellular antagonists and intracellular SMAD regulators, and its dysregulation has been associated with vascular malformations and pulmonary vascular diseases in preclinical models.

Research into BMP10-mediated signaling aims to clarify its precise roles in heart and vessel biology and to explore therapeutic strategies that target this pathway for congenital and acquired cardiovascular disorders.