AngiotensinConvertingEnzyme

AngiotensinConvertingEnzyme, often abbreviated as ACE, is a critical enzyme in the human body. It plays a central role in the renin-angiotensin-aldosterone system, a complex hormonal cascade that regulates blood pressure and fluid balance. ACE is primarily found in the lungs and kidneys, but it also exists in lower concentrations in other tissues. Its main function is to convert angiotensin I, an inactive peptide, into angiotensin II, a potent vasoconstrictor. Angiotensin II causes blood vessels to narrow, which in turn increases blood pressure. Furthermore, angiotensin II stimulates the adrenal glands to release aldosterone, a hormone that promotes sodium and water retention by the kidneys, further contributing to increased blood volume and pressure. Beyond its cardiovascular functions, ACE has also been implicated in other physiological processes, including inflammation and tissue remodeling. Due to its significant impact on blood pressure regulation, ACE inhibitors are a widely used class of medications for treating hypertension, heart failure, and certain kidney diseases. These drugs work by blocking the action of ACE, thereby reducing the production of angiotensin II and consequently lowering blood pressure.