Angiotensiinin

Angiotensiinin is a biologically active peptide that plays a crucial role in regulating blood pressure and fluid balance within the body. It is a key component of the renin-angiotensin-aldosterone system (RAAS), a complex hormonal cascade that influences cardiovascular function. Angiotensiinin is primarily formed from angiotensinogen, a precursor protein produced by the liver, through the enzymatic action of renin and angiotensin-converting enzyme (ACE). There are different forms of angiotensin, with angiotensiinin (also known as angiotensin II) being the most potent and physiologically significant.

The primary actions of angiotensiinin include vasoconstriction, which narrows blood vessels, thereby increasing blood pressure. It also stimulates the release of aldosterone from the adrenal glands. Aldosterone promotes sodium and water reabsorption in the kidneys, which further contributes to increasing blood volume and blood pressure. Furthermore, angiotensiinin has been implicated in cellular growth and proliferation in cardiovascular tissues, potentially contributing to remodeling and fibrosis. Dysregulation of the RAAS and elevated angiotensiinin levels are associated with various cardiovascular and renal diseases, including hypertension, heart failure, and kidney disease. Consequently, drugs that inhibit the RAAS, such as ACE inhibitors and angiotensin II receptor blockers (ARBs), are widely used to manage these conditions.