Angiogenesisdependent

Angiogenesisdependent refers to processes or conditions that rely on the formation of new blood vessels, a phenomenon known as angiogenesis. This biological process is critical for a wide range of physiological and pathological events. In normal physiology, angiogenesisdependent processes include wound healing, where new blood vessels are formed to supply nutrients and oxygen to the regenerating tissue, and the female reproductive cycle, particularly the development of the corpus luteum and the placenta during pregnancy. Organ growth and development also inherently depend on angiogenesis to ensure adequate vascularization.

Pathologically, many diseases exhibit angiogenesisdependent characteristics. Cancer is a prime example, as tumors require a robust blood supply to grow beyond a minimal size and to metastasize. The formation of new blood vessels within a tumor fuels its growth by delivering oxygen and nutrients and removing waste products. Inflammation, another complex process, can also be angiogenesisdependent, as inflammatory sites often recruit endothelial cells to form new vessels that facilitate the influx of immune cells and mediators. Ocular diseases, such as age-related macular degeneration, can also be driven by aberrant angiogenesisdependent neovascularization in the retina. Understanding the mechanisms and triggers of angiogenesis is therefore crucial for developing therapeutic strategies that target these angiogenesisdependent conditions.