Ang4

Ang4, also known as Angiopoietin-4, is a protein belonging to the angiopoietin family. These proteins are crucial regulators of vascular development and remodeling. Ang4 specifically plays a role in the development and maintenance of the lymphatic vascular system.

The angiopoietin family, which includes Ang1, Ang2, Ang3, and Ang4, generally interacts with the Tie receptors, primarily Tie1 and Tie2. Ang4 is known to bind to Tie2, influencing endothelial cell function and vascular integrity. While Ang1 is largely associated with stabilizing mature vessels, Ang2 can have opposing effects depending on the context. Ang4's specific role in the lymphatic system distinguishes it from its family members, contributing to processes such as lymphangiogenesis, the formation of new lymphatic vessels.

Research into Ang4 has highlighted its importance in various physiological and pathological conditions. Its involvement in lymphatic development suggests a role in fluid homeostasis and immune cell trafficking. Dysregulation of Ang4 or its signaling pathway has been implicated in certain diseases, particularly those involving aberrant lymphatic vessel formation or function, such as lymphedema or certain types of cancer where lymphatic spread is a concern. Further investigation continues to elucidate the precise mechanisms by which Ang4 exerts its effects and its therapeutic potential.