Amorolfine

Amorolfine is a topical antifungal agent of the morpholine class used to treat fungal infections of the nails (onychomycosis) and, less commonly, skin infections caused by dermatophytes, yeasts, and molds. It inhibits ergosterol synthesis by blocking two fungal enzymes—Δ14-reductase and squalene epoxidase—disrupting cell membrane formation and integrity.

The drug is most commonly applied as a nail lacquer containing 5% amorolfine, used weekly or as directed. Nail treatment typically lasts several months to a year because nails grow slowly, and the regimen may vary based on infection severity. Amorolfine is also available in topical formulations for skin infections, with treatment plans tailored to the site and organism involved.

Spectrum and efficacy: Amorolfine has broad activity against dermatophytes (such as Trichophyton species), yeasts (including Candida species), and certain molds. It is particularly used for onychomycosis when topical therapy is preferred or when oral antifungals are not suitable or desired.

Safety and cautions: The most common adverse effects are local irritation or contact dermatitis at the application site. Systemic adverse events are rare due to minimal systemic absorption. Contraindications include hypersensitivity to amorolfine or formulation excipients. Data on use in pregnancy and lactation are limited; treatment decisions should weigh potential benefits and risks. Interactions are unlikely given low systemic exposure, but concurrent use of multiple topical antifungals on the same area should be approached with caution.