AlphaFoldMultimer
AlphaFold Multimer (also called AlphaFold-Multimer) is an extension of DeepMind's AlphaFold2 that enables prediction of three-dimensional structures of protein complexes composed of multiple polypeptide chains. It is designed to predict both homomeric and heteromeric assemblies and to model interfaces between chains, addressing the challenge of protein–protein interactions and quaternary structure formation.
Methodology: The approach builds on the EvoFormer and StructureModule components of AlphaFold2 but adds multi-chain handling.
Applications and performance: In benchmark tests, AlphaFold Multimer demonstrated improved accuracy for several protein complexes compared
Availability and limitations: The AlphaFold Multimer system and related models have been disseminated through official AlphaFold
Impact: The development expanded the capability of computational structure prediction to multi-chain assemblies, supporting research in