Akitretini

Akitretini is a medication belonging to the class of drugs known as retinoids. It is a synthetic derivative of vitamin A and is primarily used to treat severe skin conditions. Akitretini works by affecting the growth and differentiation of skin cells. It helps to normalize the shedding of these cells, which are abnormally produced in certain dermatological disorders.

The most common indication for akitretini is severe psoriasis that has not responded to other treatments. It is also used for other conditions characterized by excessive skin cell buildup and thickening, such as ichthyosis and certain types of keratosis. The medication is taken orally, typically once a day.

Like all medications, akitretini has potential side effects. These can range from mild to severe and often relate to its effects on skin, mucous membranes, and other tissues. Common side effects include dry skin, dry lips, dry eyes, hair thinning, and inflammation of the lips. More serious side effects can occur and may involve changes in blood lipid levels, liver function, and bone density.

Akitretini is a potent drug and requires careful medical supervision. Due to its teratogenic potential, meaning it can cause severe birth defects, it is strictly contraindicated in pregnancy and for women who may become pregnant. Strict measures are in place to prevent pregnancy during treatment and for a period after cessation of the drug. It is also important to avoid concurrent use of certain other medications, such as tetracycline antibiotics, due to the risk of increased intracranial pressure. Regular monitoring of blood tests is essential to manage potential adverse effects.