ATRT2

Atrt2, also known as ATP-dependent RNA helicase 2, is a protein encoded by the ATRT2 gene in humans. It is a member of the DEAD-box protein family, which are characterized by a conserved motif known as the DEAD-box. This motif is essential for the RNA helicase activity of Atrt2, which involves the unwinding of double-stranded RNA molecules.

Atrt2 plays a crucial role in various cellular processes, including RNA splicing, translation, and RNA interference. It is involved in the regulation of gene expression by facilitating the unwinding of RNA secondary structures, thereby allowing for the proper functioning of ribosomes and other RNA-binding proteins.

The ATRT2 gene is located on chromosome 19q13.3. Mutations in this gene have been associated with several genetic disorders, including ataxia-telangiectasia, a rare neurodegenerative disorder characterized by progressive neurological deterioration, immune deficiency, and increased cancer risk. Additionally, Atrt2 has been implicated in the development of certain types of cancer, suggesting its potential as a therapeutic target.

Research on Atrt2 continues to uncover its diverse functions and its significance in maintaining cellular homeostasis. Understanding the molecular mechanisms underlying Atrt2's activity and its role in disease may lead to the development of novel therapeutic strategies for treating genetic disorders and cancers.