ATG2AB
ATG2AB refers to two closely related autophagy-related proteins in mammals, ATG2A and ATG2B, which are homologs of the yeast Atg2. They are large, coiled-coil proteins that function in macroautophagy, particularly in phagophore membrane expansion and autophagosome formation.
Function and mechanism: ATG2A and ATG2B act as lipid transfer and tethering factors that facilitate delivery
Localization and interactions: Both proteins localize to autophagosome precursors and ER–phagophore contact sites. They interact with
Genetics and redundancy: ATG2A and ATG2B are vertebrate paralogs with overlapping roles in autophagy. Depletion of
Structure: Both proteins are predicted to be elongated, coiled-coil molecules with distinct N- and C-terminal regions
Clinical relevance: Because of their central role in autophagy, ATG2A and ATG2B are studied in the context