APCCkomplex
APCCkomplex refers to a specific type of protein complex found in eukaryotic cells. This complex plays a crucial role in regulating the cell cycle, specifically in the process of mitosis. It is a key component of the spindle assembly checkpoint, a surveillance mechanism that ensures chromosomes are properly attached to the spindle microtubules before the cell divides.
The APCCkomplex, also known as the Anaphase-Promoting Complex/Cyclosome, functions as an E3 ubiquitin ligase. This means
Essential substrates for the APCCkomplex include proteins like securin and cyclins. The degradation of securin by
Dysregulation of the APCCkomplex can lead to severe consequences, including chromosomal instability and cancer. Therefore, its