ADAMTS45

ADAMTS45, also known as A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motif 45, is a protein that in humans is encoded by the ADAMTS45 gene. This gene is located on chromosome 12q24.3. ADAMTS45 is a member of the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motif) family of proteins, which are involved in various biological processes, including cell adhesion, cell migration, and extracellular matrix remodeling.

ADAMTS45 plays a crucial role in the development and function of the cardiovascular system. It is involved in the regulation of vascular smooth muscle cell proliferation and migration, which are essential for the formation and maintenance of blood vessels. Mutations in the ADAMTS45 gene have been associated with several cardiovascular diseases, including hypertension, aortic dissection, and coronary artery disease.

In addition to its role in cardiovascular health, ADAMTS45 has also been implicated in other physiological processes, such as wound healing and tissue repair. Its precise functions and mechanisms of action are still being investigated, but ongoing research continues to shed light on the importance of ADAMTS45 in maintaining overall health and well-being.