A9cisRetinoinsäure

A9cisRetinoinsäure, also known as 9-cis-retinoic acid or 9cRA, is a naturally occurring retinoid and a biologically active metabolite of vitamin A. It is an isomer of all-trans-retinoic acid (ATRA), another well-known retinoid. 9cRA plays a crucial role in various physiological processes within the body.

This compound functions as a ligand for specific nuclear receptors, primarily retinoid X receptors (RXRs). RXRs are transcription factors that regulate gene expression, influencing processes such as cell growth, differentiation, and apoptosis. Unlike ATRA, which primarily interacts with retinoic acid receptors (RARs), 9cRA's interaction with RXRs allows it to influence a distinct set of downstream targets.

In research, 9cRA has been investigated for its potential therapeutic applications. Its ability to modulate gene expression has led to studies exploring its effects in cancer treatment, dermatological conditions, and other diseases. While often studied alongside ATRA, the distinct signaling pathways activated by 9cRA highlight its unique biological significance. Further research continues to elucidate the full spectrum of its actions and therapeutic potential.