7q35

7q35 is a cytogenetic band on the long arm (q) of chromosome 7. In standard karyotype notation, it designates the region distal to 7q34 and proximal to 7q36. The band is defined by characteristic banding patterns observed under a microscope, and the exact base-pair coordinates for 7q35 depend on the reference genome assembly being used (such as GRCh37/hg19 or GRCh38/hg38). Because cytogenetic bands are a hybrid of cytology and molecular mapping, their precise genomic span can vary between assemblies.

The 7q35 region contains multiple genes and elements, and the density and identity of genes within a given 7q35 interval can differ with genome builds. In clinical and research contexts, this band is often considered as part of distal 7q in which copy number variations and structural rearrangements can occur. As with many distal cytogenetic bands, the phenotypic consequences of deletions or duplications involving 7q35 are heterogeneous and depend on the exact size of the CNV and which genes are affected.

Clinical significance arises when chromosomal testing detects CNVs that encompass 7q35. Reported associations include neurodevelopmental disorders and congenital anomalies in some individuals, though genotype–phenotype correlations are not fully established due to variable expressivity, incomplete penetrance, and the involvement of multiple neighboring genes. Diagnostically, 7q35 is identified through methods such as chromosomal microarray, fluorescence in situ hybridization, or sequencing approaches that map structural changes to this region.

In summary, 7q35 is a distal band of chromosome 7’s long arm used in cytogenetics to localize chromosomal changes; its clinical impact depends on specific genomic alterations within the band.