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5-Methoxy-4-methylcannabidiol, commonly referred to as 5-MeO-MC, is a psychoactive compound found in the cannabis plant. It is a derivative of cannabidiol (CBD), with the addition of a methoxy group at the 5-position on the indole ring. This modification significantly alters the compound's pharmacological properties compared to CBD.

5-MeO-MC is known for its potent hallucinogenic effects, which are believed to be mediated through its interaction with serotonin receptors, particularly the 5-HT2A receptor. Users often report visual and auditory hallucinations, as well as altered states of consciousness. The duration of these effects typically ranges from 2 to 4 hours.

The compound was first synthesized in the 1960s and has since been the subject of various studies due to its unique pharmacological profile. However, its use is largely recreational and is not approved for any medical conditions. As with any psychoactive substance, the use of 5-MeO-MC carries risks, including potential adverse effects such as anxiety, paranoia, and cardiovascular issues.

Due to its potent effects and the lack of medical approval, the use of 5-MeO-MC is generally discouraged. It is important to note that the legal status of 5-MeO-MC varies by country and region, and its possession or use may be illegal. As always, it is crucial to consult with a healthcare professional before considering the use of any psychoactive substance.