5methyltetrahydrofolátu

5-methyltetrahydrofolate, often abbreviated as 5-MTHF or L-5-MTHF, is the metabolically active form of the vitamin folate. Folate, also known as vitamin B9, is essential for numerous bodily functions, including DNA synthesis and repair, cell division, and the metabolism of amino acids. While dietary folate is found in various foods and in folic acid supplements, it must be converted by the body into its active form, 5-MTHF, to be utilized.

The body converts folic acid and other folate derivatives through a series of enzymatic steps, with the enzyme methylenetetrahydrofolate reductase (MTHFR) playing a crucial role in this pathway. 5-MTHF is the primary circulating form of folate in the blood and is directly used by cells for key biochemical reactions. One of its most important roles is in the methylation cycle, where it donates a methyl group to homocysteine, converting it back to methionine. This process is vital for DNA methylation, neurotransmitter synthesis, and the detoxification of certain compounds.

Some individuals may have genetic variations in the MTHFR gene that can affect their ability to efficiently convert folic acid into 5-MTHF. In such cases, supplementation with 5-MTHF directly may be considered to ensure adequate levels of this active folate form. It is commonly found in dietary supplements and is sometimes used in medical applications to address folate deficiency or support individuals with MTHFR gene variations.