5hmCs
5hmCs refers to 5-hydroxymethylcytosine, a modified base found in DNA. It is considered an epigenetic mark, meaning it can influence gene expression without altering the underlying DNA sequence. 5hmCs is generated from 5-methylcytosine (5mC) through a process involving the enzyme TET (ten-eleven translocation) family of dioxygenases. This hydroxylation reaction is a key step in DNA demethylation, a dynamic process that is crucial for various cellular functions.
The presence and location of 5hmCs are not random. It is enriched in actively transcribed genes and
The study of 5hmCs has gained significant attention due to its potential involvement in a wide range