5alfa
5alfa is a stylized term that is often used to denote 5-alpha related concepts, particularly in biochemistry and endocrinology. In this context, it commonly refers to the family of enzymes known as 5-alpha reductases, which catalyze the conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen. There are three human isoenzymes: 5α-reductase type 1 (SRD5A1), type 2 (SRD5A2), and type 3 (SRD5A3). They differ in tissue distribution and activity, with SRD5A2 being crucial in male genital development and SRD5A1 contributing more broadly to peripheral tissues.
Function and physiology: 5-alpha reductases reduce the delta4,5 double bond in steroids, enabling the synthesis of
Medical relevance: Pharmacological inhibitors of 5-alpha reductase, such as finasteride (selective for type 2) and dutasteride
Notes: The exact meaning of 5alfa can vary with context, and in non-scientific usage it may appear