400mgkg1

400mgkg1 is a unit of measurement commonly encountered in pharmacology and toxicology. It represents a dosage of 400 milligrams of a substance per kilogram of body weight. This unit is crucial for standardizing drug administration and assessing the potential toxicity of chemicals across individuals of varying sizes.

When administering a medication or evaluating the effects of a compound, researchers and clinicians often express the dose in terms of milligrams per kilogram (mg/kg). This ensures that the amount of substance delivered is proportional to the recipient's mass, providing a more consistent and comparable measure than simply stating a total milligram amount. The "1" in 400mgkg1 is often implied or omitted in common usage, but it signifies the per kilogram component of the unit.

For example, if a study reports an effective dose of 400mgkg1 for a particular drug in an animal model, it means that for every kilogram of body weight the animal possesses, 400 milligrams of the drug were administered. This same principle applies when considering the potential toxicity of substances. A toxicological study might determine a lethal dose of 400mgkg1, indicating the amount of a substance that is likely to cause death in a significant portion of the population when administered at that concentration relative to body weight. The use of mg/kg allows for more accurate extrapolations between different species and individuals.