3butyn1ol

3butyn-1-ol is an organic compound with the chemical formula C4H6O. It is an unsaturated alcohol containing a terminal alkyne functional group and a primary alcohol functional group. This dual functionality makes it a versatile building block in organic synthesis. It is a colorless liquid at room temperature and is soluble in many organic solvents.

The synthesis of 3butyn-1-ol can be achieved through various methods, often involving the reaction of acetylene with an epoxide or haloalkane. One common route involves the reaction of propargyl bromide with formaldehyde in the presence of a suitable base. Another approach utilizes the Grignard reagent derived from propargyl bromide reacting with ethylene oxide.

Due to the presence of both an alkyne and an alcohol, 3butyn-1-ol can undergo a wide range of chemical transformations. The alkyne moiety can participate in addition reactions, cycloadditions (such as the click reaction), and metal-catalyzed couplings. The alcohol group can be oxidized to an aldehyde or carboxylic acid, esterified, or converted into a leaving group for nucleophilic substitution. These reactions allow for the construction of more complex molecules, including pharmaceuticals, fragrances, and polymers. Its applications are primarily as an intermediate in the synthesis of other organic compounds.