35Dichlorophenyl

3,5-Dichlorophenyl is a phenyl substituent used in organic chemistry. It refers to a benzene ring in which chlorine atoms occupy the 3 and 5 positions relative to the bond that links the ring to the rest of the molecule. This creates a meta-disubstituted phenyl group that is symmetric with respect to the 1-position connection. The term is often written as 3,5-dichlorophenyl or 3,5-dichloro­phenyl in shorthand.

Chemically, the chlorine atoms are electron-withdrawing by induction, which reduces the ring’s reactivity toward further electrophilic substitution and can influence the properties of compounds bearing the group. The 3,5-dichloro­phenyl substituent also increases lipophilicity and can affect metabolic stability. The overall behavior depends on the other substituents and the larger molecular framework.

3,5-Dichlorophenyl groups appear in a variety of synthetic compounds used in pharmaceuticals, agrochemicals, and dyes. As a substituent, they can modulate properties such as polarity, binding interactions, and routes of metabolism.

Safety and handling: chlorinated aromatics can be hazardous; exposure may irritate skin and eyes, and some compounds are persistent in the environment. Handle with appropriate personal protective equipment and follow regulatory guidelines for disposal.

See also: dichlorophenyl, chlorophenyl, aryl chloride.