2deoxyglucose6phosphate

2-Deoxy-D-glucose (2-DG) is a glucose analog that lacks a hydroxyl group at the 2-position. This modification renders it resistant to metabolism by hexokinase, an enzyme that typically catalyzes the first step in glucose metabolism. As a result, 2-DG is not readily phosphorylated and cannot enter the glycolytic pathway. Instead, it is transported into cells and accumulates in the cytoplasm, where it can interfere with various cellular processes. 2-DG is commonly used as a metabolic tracer and inhibitor in biological research. Its resistance to phosphorylation allows it to accumulate in cells, providing a means to study cellular metabolism and function. Additionally, 2-DG has been employed in the development of diagnostic tools for glucose-6-phosphate dehydrogenase deficiency, a genetic disorder affecting red blood cell metabolism. The compound's unique properties make it a valuable tool in both research and clinical settings.