2Hydroxyestradiol
2-Hydroxyestradiol, also known as 2-OHE2, is a catechol estrogen and a metabolic product of estradiol formed by hydroxylation at the 2-position of the A-ring. In humans, this reaction is catalyzed by cytochrome P450 enzymes, including members of the CYP1 family such as CYP1A1, CYP1A2, and CYP1B1, generating 2-hydroxyestradiol alongside other hydroxylated estrogens.
Biological activity of 2-hydroxyestradiol is generally distinct from that of estradiol. It typically exhibits reduced affinity
Metabolism and detoxification occur primarily through catechol-O-methyltransferase (COMT), which methylates 2-hydroxyestradiol to form 2-methoxyestradiol (2-MeOE2). 2-MeOE2
Clinical and research relevance centers on the balance of estrogen metabolism, particularly the relative levels of
See also: 4-hydroxyestradiol, 2-methoxyestradiol, catechol estrogens, estradiol.