2Deoxy6phosphoglucose

2-Deoxy-6-phosphoglucose (2-DPG) is a phosphorylated derivative of glucose that plays a crucial role in the oxygen transport and utilization within red blood cells. It is formed through the glycolytic pathway, where glucose is converted into 2-DPG by the enzyme 2-deoxyglucose-6-phosphate phosphoglucomutase. The presence of 2-DPG in red blood cells is essential for the efficient transport of oxygen from the lungs to the tissues. It binds to deoxyhemoglobin, shifting the oxygen dissociation curve to the right, thereby facilitating the release of oxygen in peripheral tissues. The concentration of 2-DPG in red blood cells is regulated by various factors, including pH, carbon dioxide levels, and the availability of glucose. Elevated levels of 2-DPG are associated with conditions such as chronic hypoxia and anemia, while decreased levels are seen in conditions like chronic obstructive pulmonary disease and diabetes. The measurement of 2-DPG levels in blood is a useful diagnostic tool for assessing oxygen transport and utilization in various clinical settings.