1R00

1R00 is a grant-number designation used within the United States National Institutes of Health (NIH) funding system. It specifically appears as the component of grant numbers for the R00 mechanism, which is the independent research phase of the K99/R00 Pathway to Independence Award. In this context, 1R00 does not denote a separate program on its own but identifies the grant during its R00 stage in NIH records and databases. The R00 portion funds the recipient’s independent research after successfully completing the mentored K99 phase.

The K99/R00 Pathway to Independence Award is designed to help promising postdoctoral researchers transition to independent research careers. Applicants typically pursue a mentored K99 phase to develop skills, gather preliminary data, and establish a track record, followed by the R00 phase that provides independent project funding. The R00 phase is intended to support the establishment of an independent research program, often for a limited multi-year period, contingent on securing an independent position and satisfying program requirements.

Eligibility criteria generally emphasize scientific maturity, potential for independence, and institutional support. Applications evaluate the candidate’s scientific trajectory, publication record, proposed research plan, and the suitability of the host institution and mentor. The program aims to accelerate transition to independent funding and to enhance early-career researchers’ competitiveness for future NIH support. The 1R00 designation is primarily a technical identifier within grant administration rather than a separate entity or program description. See also K99/R00 Pathway to Independence Award.