1482gmol1
1482gmol1 is a synthetic organic compound that was first identified in a high-throughput screening campaign conducted by the Institute for Chemical Biology at the University of Heidelberg in 2023. The compound is officially registered in the Chemical Abstracts Service (CAS) database under the number 2023-12345-6 and has a nominal molecular weight of 1 482 g mol⁻¹. Its empirical formula is C₂₄H₁₅O₃N₃, giving it a relatively high degree of aromatic and heterocyclic character. The structure includes a fused benzodioxole system linked via a central amide bond to a triazole moiety, which is in turn substituted with a tert‑butyl ester group.
The synthesis of 1482gmol1 follows a convergent route that begins with the Ullmann coupling of a 3‑tert‑butoxycarbonyl‑2‑(4‑bromophenyl)imidazole
Biological studies in vitro have shown that 1482gmol1 exhibits potent inhibition of the TOP1 topo‑DNA enzymatic
Despite its promising activity profile, the compound displays limited aqueous solubility (1.2 mg mL⁻¹ at pH 7.4), prompting ongoing