zdti
ZDTI, or Zinc-Dependent Translocase Inhibitor, is a class of antibiotics that inhibit the activity of the zinc-dependent translocase (ZntA) protein in bacteria. This protein is essential for the transport of essential nutrients, such as iron and zinc, into the bacterial cell. By inhibiting ZntA, ZDTIs prevent the bacteria from acquiring these nutrients, leading to their death.
ZDTIs are typically used to treat infections caused by Gram-negative bacteria, which are resistant to other
ZDTIs work by binding to the active site of ZntA, preventing the protein from transporting nutrients into
ZDTIs are generally well-tolerated, but like all antibiotics, they can cause side effects such as gastrointestinal