ZDTI

ZDTI, or Zinc-Dependent Translocase Inhibitor, is a class of antibiotics that inhibit the activity of the zinc-dependent translocase (ZntA) protein in bacteria. This protein is essential for the transport of essential nutrients, such as iron and zinc, into the bacterial cell. By inhibiting ZntA, ZDTIs prevent the bacteria from acquiring these nutrients, leading to their death.

ZDTIs are typically used to treat infections caused by Gram-negative bacteria, which are resistant to other classes of antibiotics. They are often used in combination with other antibiotics to enhance their effectiveness. Examples of ZDTIs include aztreonam and ceftazidime.

ZDTIs work by binding to the active site of ZntA, preventing the protein from transporting nutrients into the bacterial cell. This results in a depletion of essential nutrients, leading to the death of the bacteria. However, ZDTIs are not effective against Gram-positive bacteria or bacteria that do not express ZntA.

ZDTIs are generally well-tolerated, but like all antibiotics, they can cause side effects such as gastrointestinal upset, allergic reactions, and drug interactions. They should be used only when necessary and under the guidance of a healthcare professional.